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Genetic variation in immunity and disease resistance in dairy cows and other livestock

Code: 9781838791797
Michael Stear, Karen Fairlie-Clarke, and Nicholas Jonsson, University of Glasgow, UK; Bonnie Mallard, University of Guelph, Canada; and David Groth, Curtin University, Australia

Chapter synopsis: For most diseases of economic importance in livestock, resistance can be considered to be a complex or quantitative trait with limited evidence of negative correlations with resistance to other diseases. Attention to such traits allows the selection of healthier and more productive animals. This chapter reviews the sources of variation in resistance to disease, and then considers three strategies for selecting for resistance: by directly selecting for resistance to important diseases, based on the incidence of disease or a disease-related marker; by selecting for animals with strong innate and/or adaptive immune responses to a specified challenge to achieve a broad-based disease resistance; and by selecting for animals that perform well in an environment in which disease is endemic. The discussion also covers high-density SNP chips, improved sequencing methodologies and genome-wide association studies (GWAS)

DOI: £25.00
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Table of contents 1 Introduction 2 Genetic variation in resistance to disease 3 The sources of genetic variation in resistance to disease 4 Strategies for breeding to increase resistance to disease 5 Case study 1: resistance to cattle tick infestation 6 Case study 2: mastitis in cattle 7 Case study 3: bovine respiratory disease (BRD) complex 8 Case study 4: additive and non-additive genetic variation 9 Conclusions 10 Where to look for further information 11 References

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