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Genetics and genomics of immunity and disease traits in poultry species

Code: 9781786767783
M.-H. Pinard-van der Laan, INRAE, France; J. Kaufman, University of Edinburgh and University of Cambridge, UK; A. Psifidi, Royal Veterinary College, UK; H. Zhou, University of California- Davis, USA; and M. Fife, Aviagen Ltd and The Pirbright Institute, UK

Chapter synopsis: A major current challenge in achieving sustainable poultry production is reducing risk to animal and human health. Strategies to control poultry diseases utilise selective breeding to enhance immunity and disease resistance. However, immune and disease resistance traits are difficult to measure, moderately heritable and of complex polygenic architecture. Consequently, only recently have poultry breeding programmes addressed health related traits. This chapter discusses the advances in genetic, genomic and functional genomic studies of immune and disease resistance in chickens and the role of the MHC. It reviews multi-trait selection experiments and discuss potential trade-offs between production and immunocompetence and the response to disease. These reveal significant genetic variation, in specific loci playing an important role in immune and disease resistance traits, however, further interdisciplinary studies are required to elucidate the underlying mechanisms. In conclusion, selective breeding has the potential to provide an accurate, environmentally friendly and cost-effective approach to disease control.

DOI: 10.19103/AS.2020.0065.14
Table of contents 1 Introduction 2 Deciphering the role of immune response genes in chicken: the major histocompatibility complex 3 The genetic architecture of immune traits: lessons from selection experiments 4 The contribution of ‘omics’ to immune responses and disease resistance 5 Breeding for disease resistance in poultry species 6 Trade-offs between immunocompetence and production in chicken 7 Genome-wide association case study 1: deciphering genetics and genomics of immune responses to Salmonella 8 Genome-wide association case study 2: deciphering genetics and genomics of immune responses to Campylobacter 9 Conclusion and future trends 10 References

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