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Progress in precise and predictable genome editing in plants with base editing

Code: 9781801460972
Sabine Fräbel, Shai J. Lawit, Jingyi Nie, David G. Schwark, Thomas J. Poorten and Nathaniel D. Graham, Pairwise Plants, USA

Chapter synopsis: Base editors are gene editing tools that allow targeted nucleic acid conversions, most commonly C>T and A>G, through pairing of deamination domains with impaired nucleases. Multiple deaminase domains and architectures have been demonstrated in planta across a wide array of species, with both cytosine and adenine base editing frequencies being observed at over 80%. The ability of base editors to introduce nucleic acid diversity while maintaining the same reading frame should make them powerful tools for plant genetic editing moving forward.

DOI: 10.19103/AS.2020.0082.06

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Table of contents 1 Introduction 2 Progress in mammalian systems 3 Cytosine base editing in plants 4 Adenine base editing in plants 5 Broadening protospacer adjacent motif (PAM) accessibility 6 Sequence diversification in crops 7 Off-target base editing 8 Current applications of base editors in crops 9 Conclusion 10 Where to look for further information 11 References

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